Dunno about the guinea pig as I fast-forwarded through the video stopping for intermittent snippets.
Laika was the dog fired into orbit, on a Soviet Sputnik in 1957. She died quite soon into the mission but the vessel completed over 2,000 orbits before breaking up in 1958.
I think the first animals to go into orbit and return to earth alive were two monkeys in 1959, aboard an American Jupiter rocket.